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TissueArray.com LLC human hnc tissue microarray paraffin sections
TRIB3 expression is positively correlated with the poorer overall survival in the TCGA <t>HNC</t> dataset. (A) The differential expression levels of TRIB3 mRNA in normal (green) and HNC (red) tissues were analyzed using the Gene Expression Profiling Interactive Analysis 2 website, a tool for analyzing TCGA RNA sequencing data . The expression data were first log2(TPM+1) transformed for differential analysis and presented as log2FC, which is defined as the median level of tumor samples-the median level of normal samples. Data were presented as mean ± SD. Tumor samples, n=519; normal samples, n=44, according to the information of TCGA database. (B) TRIB3 mRNA expression levels in 19 paired HNSC and normal tissues from the TCGA database were compared using the paired Student's t-test. (C) Overall survival curves for patients with HNSC with the highest 25% (n=124) and the lowest 25% (n=124) TRIB3 mRNA expression levels were analyzed using Kaplan Meier curves and the log-rank test. * P<0.05; *** P<0.001. TRIB3, tribbles pseudokinase 3; TCGA, The Cancer Genome Atlas; HNC, head and neck cancer; HNSC, head-neck squamous cell carcinoma.
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TRIB3 expression is positively correlated with the poorer overall survival in the TCGA HNC dataset. (A) The differential expression levels of TRIB3 mRNA in normal (green) and HNC (red) tissues were analyzed using the Gene Expression Profiling Interactive Analysis 2 website, a tool for analyzing TCGA RNA sequencing data . The expression data were first log2(TPM+1) transformed for differential analysis and presented as log2FC, which is defined as the median level of tumor samples-the median level of normal samples. Data were presented as mean ± SD. Tumor samples, n=519; normal samples, n=44, according to the information of TCGA database. (B) TRIB3 mRNA expression levels in 19 paired HNSC and normal tissues from the TCGA database were compared using the paired Student's t-test. (C) Overall survival curves for patients with HNSC with the highest 25% (n=124) and the lowest 25% (n=124) TRIB3 mRNA expression levels were analyzed using Kaplan Meier curves and the log-rank test. * P<0.05; *** P<0.001. TRIB3, tribbles pseudokinase 3; TCGA, The Cancer Genome Atlas; HNC, head and neck cancer; HNSC, head-neck squamous cell carcinoma.

Journal: International Journal of Molecular Medicine

Article Title: Tribbles pseudokinase 3 drives cancer stemness in oral squamous cell carcinoma cells by supporting the expression levels of SOX2 and EGFR

doi: 10.3892/ijmm.2025.5485

Figure Lengend Snippet: TRIB3 expression is positively correlated with the poorer overall survival in the TCGA HNC dataset. (A) The differential expression levels of TRIB3 mRNA in normal (green) and HNC (red) tissues were analyzed using the Gene Expression Profiling Interactive Analysis 2 website, a tool for analyzing TCGA RNA sequencing data . The expression data were first log2(TPM+1) transformed for differential analysis and presented as log2FC, which is defined as the median level of tumor samples-the median level of normal samples. Data were presented as mean ± SD. Tumor samples, n=519; normal samples, n=44, according to the information of TCGA database. (B) TRIB3 mRNA expression levels in 19 paired HNSC and normal tissues from the TCGA database were compared using the paired Student's t-test. (C) Overall survival curves for patients with HNSC with the highest 25% (n=124) and the lowest 25% (n=124) TRIB3 mRNA expression levels were analyzed using Kaplan Meier curves and the log-rank test. * P<0.05; *** P<0.001. TRIB3, tribbles pseudokinase 3; TCGA, The Cancer Genome Atlas; HNC, head and neck cancer; HNSC, head-neck squamous cell carcinoma.

Article Snippet: A human HNC tissue microarray paraffin sections containing 70 samples were purchased from TissueArray.Com (cat. no. HN802d).

Techniques: Expressing, Quantitative Proteomics, Gene Expression, RNA Sequencing, Transformation Assay

TRIB3 expression is positively correlated with E2F1, SOX2 and EGFR expression in HNC tissues. (A) Representative immunohistochemistry images of TRIB3, E2F1, SOX2 and EGFR expression in human HNC tissue microarray samples. Scale bar, 50 μ m. Correlation analyses of protein expression levels in 70 HNC tissue samples: (B) TRIB3 vs. E2F1 (C) TRIB3 vs. SOX2 (D) E2F1 vs. SOX2 and (E) TRIB3 vs. EGFR. Staining intensities were quantified using TissueFAXS software (version 7.0; TissueGnostics GmbH) and expressed as pixel density. Correlations were analyzed using Pearson's correlation coefficient (r). n=70. TRIB3, tribbles pseudokinase 3; IHC, immunohistochemistry; E2F1, E2F transcription factor 1; HNC, head and neck cancer.

Journal: International Journal of Molecular Medicine

Article Title: Tribbles pseudokinase 3 drives cancer stemness in oral squamous cell carcinoma cells by supporting the expression levels of SOX2 and EGFR

doi: 10.3892/ijmm.2025.5485

Figure Lengend Snippet: TRIB3 expression is positively correlated with E2F1, SOX2 and EGFR expression in HNC tissues. (A) Representative immunohistochemistry images of TRIB3, E2F1, SOX2 and EGFR expression in human HNC tissue microarray samples. Scale bar, 50 μ m. Correlation analyses of protein expression levels in 70 HNC tissue samples: (B) TRIB3 vs. E2F1 (C) TRIB3 vs. SOX2 (D) E2F1 vs. SOX2 and (E) TRIB3 vs. EGFR. Staining intensities were quantified using TissueFAXS software (version 7.0; TissueGnostics GmbH) and expressed as pixel density. Correlations were analyzed using Pearson's correlation coefficient (r). n=70. TRIB3, tribbles pseudokinase 3; IHC, immunohistochemistry; E2F1, E2F transcription factor 1; HNC, head and neck cancer.

Article Snippet: A human HNC tissue microarray paraffin sections containing 70 samples were purchased from TissueArray.Com (cat. no. HN802d).

Techniques: Expressing, Immunohistochemistry, Microarray, Staining, Software